The externalizing GWAS performed by the Externalizing Consortium and reported in Karlsson Linnér et al. (Under Review) included GWAS summary statistics contributed by 23andMe. These summary statistics had previously been analyzed in studies by Liu et al. (2019) and Pasman et al. (2018), which were included in the genomic SEM model reported in Karlsson Linnér et al. (Under Review). Accordingly, before we can provide summary statistics from the externalizing GWAS, you must obtain permission from 23andMe.  To obtain the externalizing GWAS summary statistics, please follow the below procedures:

  1. (a) Fill out this form to request access to the externalizing GWAS summary statistics from the principal investigators of the Externalizing Consortium AND (b) initiate a request with 23andMe through the 23andMe Publication Dataset Access Procedure.
  2.  
    In your data access request, indicate that you are requesting permission to work with the externalizing GWAS summary statistics from Karlsson Linnér et al. (Under Review), which utilized GWAS summary statistics from the following two studies that contained contributing data from 23andMe:

    Liu et al., Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Nat. Genet. 51, 237–244 (2019).

    Pasman et al., GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. Nat. Neurosci. 21, 1161–1170 (2018).

    Note that you do not need the actual summary statistics from 23andMe, you are only requesting permission to obtain the externalizing GWAS summary statistics from us.

  3. Once your institution has signed a Data Transfer Agreement and Statement of Work, you will receive an email from dataset-request@23andme.com giving you permission to receive the externalizing summary stats. Forward this request to Danielle Dick at edgelab@vcu.edu and Richard Karlsson Linnér at r.karlssonlinner@vu.nl. We will then provide the externalizing GWAS summary statistics.
  4.  

  5. All publications using the externalizing summary statistics should be sent to 23andMe, with copy to ddick@vcu.edu, to confirm that the topic of the paper is in the scope of the project as described in the Statement of Work with 23andMe and that the 23andMe research participant acknowledgment and Externalizing Consortium acknowledgment has been included.